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Filling Your Prescription
How is my XYREM® prescription filled?[1]
All XYREM prescriptions are filled by a central, mail order pharmacy.
What does the central pharmacy do?[1]
- Your doctor sends the XYREM prescription directly to the pharmacy.
- A team member from the pharmacy will contact you within 48 hours of receiving your prescription to review insurance information. For more information, see Insurance Coverage.
- The pharmacy will confirm that you have received and/or understood this educational booklet. If your physician did not provide these materials to you, the pharmacy will review them with you before sending your first shipment of XYREM.
- The pharmacy will always confirm where and when you would like XYREM delivered and who will sign for the shipment. XYREM will be shipped via an overnight courier. When the courier arrives you, or someone you designate, must sign for your XYREM delivery.
What will I receive with my shipment of XYREM?[1]
With each shipment you receive, there will be 1 or more bottles of XYREM, a liquid measuring device, 2 dosing cups with child-resistant caps and a printed medication guide.
Can my local pharmacy provide XYREM?[1]
No, but in some cases, you may be able to have the courier deliver XYREM to your local pharmacy for later pickup.
What does it mean that XYREM is a controlled substance?[1]
The active ingredient of XYREM is a form of GHB and has been a target for persons who abuse drugs. Because XYREM is a controlled substance, it is illegal for you to sell or give your XYREM to anyone else, or to use your XYREM for purposes other than those for which it was prescribed. As with all controlled substances, failure to adhere to these rules may result in punishment under federal and state law by jail and fines.
Therefore, your XYREM must be:
- used only by you.
- used only as directed by your physician.
- stored in a safe and secure place.
Remember to refill your XYREM prescription[1]
When you have only a 7-day supply of XYREM remaining, call the Success Program® to request your next shipment. Be ready to tell the pharmacy team where you would like the prescription delivered and the name of the adult who will sign for the package.
The pharmacy team will arrange for you to receive a refill the next day via Federal Express delivery. Saturday delivery service is available at no additional charge. The pharmacy team can also arrange for you or your designated recipient to pick up the package at a Federal Express depot. If you choose that shipping method, the pharmacy team will call to give you the Federal Express tracking number when your refill has been shipped. You or your designated recipient must have the tracking number to pick up the package.
While the pharmacy team will track your XYREM use and call as your refill time approaches, do not wait for their phone call. Make sure there is no interruption in your therapy. When you see your prescription running low, call the Success Program at 1-866-XYREM88® (1-866-997-3688).
Obtaining a new prescription after your last refill[1]
When the last refill of your current XYREM prescription is shipped, the pharmacy team will enclose a card in the package to notify you. The pharmacy team will also make the refill process easy by sending a fax to your doctor, requesting that a new XYREM prescription be submitted to the pharmacy team. The pharmacy team will track your XYREM use and call as your refill time approaches, but do not wait for their phone call. When you see your prescription running low, call them to request your next refill.
Important Safety Information
1. XYREM® is a controlled substance. Controlled substances are medicines that, if abused, may lead to varying degrees of physical or psychological dependence. XYREM is a Schedule III drug — which means that it has a moderate dependence liability. If you sell, distribute, or give your XYREM to anyone else or use it for purposes other than what it was prescribed for, you may be punished under federal and state law by jail and fines.
2. It is very important to keep XYREM out of reach of children and pets.
3. XYREM can cause serious side effects including trouble breathing while asleep, confusion, abnormal thinking, depression and loss of consciousness. Tell your doctor if you have any of these problems while taking XYREM.
BOXED WARNING:
!Warning
Central Nervous System Depressant with Abuse Potential. Should not be used with alcohol or other CNS depressants. Sodium oxybate is a form of GHB, a known drug of abuse. Abuse has been associated with some important central nervous system (CNS) adverse events (including death). Even at recommended doses, use has been associated with confusion, depression, and other neuropsychiatric events. Reports of respiratory depression occurred in clinical trials. Almost all of the patients who received sodium oxybate during clinical trials were receiving CNS stimulants.
Important CNS adverse events associated with abuse of GHB include seizure, respiratory depression and profound decreases in level of consciousness, with instances of coma and death. For events that occurred outside of clinical trials, in people taking GHB for recreational purposes, the circumstances surrounding the events are often unclear (e.g., dose of GHB taken, the nature and amount of alcohol or any concomitant drugs).
XYREM is available through the XYREM Success Program®, using a centralized pharmacy 1-866-XYREM88® (1-866-997-3688). The Success Program provides educational materials to the prescriber and the patient explaining the risks and proper use of sodium oxybate, and the required prescription form. Once it is documented that the patient has read and/or understood the materials, the drug will be shipped to the patient. The XYREM Success Program also recommends patient follow-up every 3 months. Physicians are expected to report all serious adverse events to the manufacturer.
